| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a compound of formula I or use thereof to prepare a medicine for treating depression, anxiety or both: or pharmaceutically acceptable salts thereof, where m is 0-3; n is 0-2; Ar is: optionally substituted indolyl; optionally substituted indazolyl; azaindolyl; 2,3-dihydro-indolyl; 1,3-dihydro-indol-2-one-yl; optionally substituted benzothiophenyl; benzothiazolyl; benzisothiazolyl; optionally substituted quinolinyl; 1,2,3,4-tetrahydroquinolinyl; quinolin-2-one-yl; optionally substituted naphthalenyl; optionally substituted pyridinyl; optionally substituted thiophenyl or optionally substituted phenyl; R 1 is: C 1-6 alkyl; hetero-C 1-6 alkyl; halo-C 1-6 alkyl; halo-C 2-6 alkenyl; C 3-7 cycloalkyl; C 3-7 cycloalkyl-C 1-6 alkyl; C 1-6 alkyl-C 3-6 cycloalkyl-C 1-6 alkyl; C 1-6 alkoxy; C 1-6 alkylsulphonyl; phenyl; tetrahydropyranyl-C 1-6 alkyl; phenyl-C 1-3 alkyl, where the phenyl part is optionally substituted; heteroaryl-C 1-3 alkyl; R 2 is: hydrogen or C 1-6 alkyl; and each R a and R b is independently: hydrogen; C 1-6 alkyl; C 1-6 alkoxy; halo; hydroxy or oxo; or R a and R b together form C 1-2 alkylene; under the condition that, when m is 1, n is 2, and Ar is an optionally substituted phenyl, then R 1 is not methyl or ethyl, and where optionally substituted denotes 1-3 substitutes selected from alkyl, cycloalkyl, alkoxy, halo, haloalkyl, haloalkoxy, cyano, amino, acylamino, monoalkylamino, dialkylamino, hydroxyalkyl, alkoxyalkyl, pyrazolyl, -(CH 2 ) q -S(O) r R f ; -(CH 2 ) q -C(=O)-NR g R h ; -(CH 2 ) q -N(R f )-C(=O)-R i or -(CH 2 ) q -C(=O)-R i ; where q is 0, r is 0 or 2, each R f , R g and R h is independently hydrogen or alkyl, and each R i is independently alkyl, and where "heteroaryl" denotes a monocyclic radical having 5-6 ring atoms, including 1-2 ring heteroatoms selected from N or S, wherein the rest of the ring atoms are C atoms, "heteroalkyl" denotes an alkyl radical, including a branched C 4 -C 7 -alkyl, where one hydrogen atom is substituted by substitutes selected from a group consisting of -OR a , -NR b H, based on the assumption that the bonding of heteroalkyl radical occurs through a carbon atom, where R a is hydrogen or C 1-6 alkyl, R b is C 1-6 alkyl. Pharmaceutical compositions based on said compound are also disclosed. n EFFECT: obtaining novel compounds which can be used in medicine to treat depression, anxiety or both. n 14 cl, 1 tbl, 28 ex |