http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2477724-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7c0846c26a79c5260094729617d092d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 |
| filingDate | 2008-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14432b9892aaf0dab3bea2cd4a85eafe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79661f29862651898a6572cbb03a48b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e70df84b7b8007ae7a98553454322b33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9228ebb98c23886a0c3de3a32fb8346f |
| publicationDate | 2013-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2477724-C2 |
| titleOfInvention | Mdm2 and p53 interaction inhibitors |
| abstract | FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to compounds of formula n n n n wherein m is equal to 0, 1, 2; n is equal to 0, 1, 2, 3; each p, s, t is equal to 0 or 1; X represents CHR 8 wherein R 8 represents hydrogen; represents -CR 9 =C<, and then a dash line represents a bond, R 9 independently represents hydrogen or C 1-6 -alkyl, or wherein R 9 together with one of R 2 or R 20 forms a direct bond; R 1 represents hydrogen; R 2 and R 20 are specified in: halogen, cyano, polyhalogen-C 1-6 -alkyl, C 1-6 -alkyl, morpholinyl, C 1-6 -alkyloxy with any of said groups is optionally and independently substituted by hydroxy, NR 21 R 22 wherein R 21 and R 22 are independently specified in hydrogen, C 1-6 -alkylcarbonyl; or R 2 and R 20 together with a phenyl cycle whereto attached form a naphthaline group; or one of R 2 or R 20 have the values specified above, and the other of R 2 or R 20 together with R 9 form a direct bond; R 3 represents hydrogen; R 4 and R 5 independently represent hydrogen, C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, C 2-6 -alkenyl or C 1-6 -alkyloxy; or R 6 represents hydrogen; when p is equal to 1, then R 7 represents hydrogen; Z represents one of the radicals presented in the patent claim. Also, the invention refers to a based pharmaceutical composition, using the compounds of formula (I) for producing the drug preparation for treating the disorders medicated by p53-MDM2 interaction for treating cancer, and to methods for producing the compounds of formula (I). n EFFECT: preparing the compounds of formula (I) as p53-MDM2 interaction inhibitors. n 13 cl, 5 tbl, 31 ex |
| priorityDate | 2007-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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