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filingDate 2008-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00c9b0347f382862517382279f8d2d1f
publicationDate 2013-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2476455-C2
titleOfInvention Nontoxic polethoxysiloxane-based substance for making biologically resorbable and/or biologically active articles containing polyethoxysilane-based substance, production and use thereof
abstract FIELD: chemistry. n SUBSTANCE: invention relates to polyethoxysiloxanes and use thereof. Disclosed is a polyethoxysiloxane (PES) based substance which is obtained through (a) a first reaction for hydrolysis-condensatio of tetraethoxysilane of formula SiX 4 (I), wherein X is an ethoxy group, which is catalysed by an acid at initial pH from 0 to ≤7 in the presence of ethanol or a mixture of ethanol and water as a solvent for 1-24 hours at temperature of 0-78°C, the initial pH being established using diluted nitric acid or an acid mixture of a physiologically transferred acid and a substrate made from nitroxide synthase, (b) a second reaction of hydrolysis-condensation of the substance obtained at step (a), and simultaneous removal of the solvent by gradual evaporation in a closed, gas-impermeable container at pressure of 100-1013 mbar and temperature of 50-78°C, until sharp increase in viscosity (at shear velocity of 10 s -1 at 4°C) to 0.5-2 Pa·s, until achieving constant weight and until formation of cyclotetrasiloxane of general formula ((SiO(OH) 0.75 (OEt) 1.25 ×1/64 H 2 O) 4 and molar mass 4 x about 114 g = about 456 g, (c) cooling the PES in a closed container for a period ranging from a few minutes to a few hours and (d) converting the PES obtained at step (c) into a PES substance through a third hydrolysis-condensation reaction. Use of the obtained substance is also disclosed. n EFFECT: obtained substance is non-toxic and its sol solution is suitable for spinning. n 12 cl, 1 ex
priorityDate 2007-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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