| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to organic chemistry, specifically to 16-(1,2,4-oxadiazol-3-yl)-15,16-epoxilabdanoids of formula n n n n wherein R=Me(Ia), Ph(1b), CH 2 Cl(lc) possessing an ability to inhibit human tumour cell growth. The compounds are produced of lambertianic acid contained in Siberian cedar gum and fir needles. n EFFECT: there are produced new compounds which possess considerable cytotoxic activity on human tumour cells. n 1 cl, 1 tbl, 4 ex |