| abstract |
FIELD: chemistry. n SUBSTANCE: peptides and peptide derivatives have general formula Sub 1 -X 1 NX 2 X 3 PVYIPX 4 X 5 RPPHP-Sub 2 , where Sub 1 , X 1 , X 2 , X 3 , X 5 , Sub 2 are given in the claim. The disclosed peptides or peptide derivatives have at least one of the following advantages compared to natural apidecine peptides: (i) longer half-life in mammal serum owing to higher protease stability, (ii) high antimicrobial activity with respect to one or more bacterial strains, particularly human pathogens or fungi, or other microbial infections, (iii) demonstrate a wide range of antimicrobial activity, (iv) cause slower development of resistance in microorganisms and (v) are not toxic for human cells, including erythrocytes. n EFFECT: improved properties of peptides. n 21 cl, 8 dwg, 7 tbl, 6 ex |