http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2470008-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d6438696a393c16bc06bbff9098c25d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ccc73308f50bfee1f5db69ec0e7d208 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 |
| filingDate | 2011-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_852f0ba604a96e2bacf16580beb1d0bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d1b80c716d6254aa32082e115fce6ba |
| publicationDate | 2012-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2470008-C1 |
| titleOfInvention | Method of producing (13c2-carbonyl)dimethyl phthalate |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to a method of producing ( 13 C 2 -carbonyl)dimethyl phthalate which can be used to produce ( 13 C 2 -carboxy)phthalic acid. Both compounds can be used to produce a range of agents for tumour diagnosis and therapy. The disclosed method involves carbonylation of 1,2-dibromobenzene with carbon monoxide 13 CO in methanol at temperature of 100-150°C, pressure of not more than 1.0 MPa, in the presence of a catalyst system containing palladium acetate and a phosphine ligand, taken in molar ratio of 1:0.5-1:10, in the presence of triethylamine or sodium acetate. The method enables to obtain a product with output of up to 94.5% with isotopic purity of up to 99.3%. Catalyst efficiency reaches 9.9 mol/mol-h. ( 13 C 2 -carboxy)phthalic acid with isotopic purity of 99% can be obtained from the obtained product via acid hydrolysis. n EFFECT: high output of the end product. n 2 cl, 5 ex |
| priorityDate | 2011-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.