http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2469039-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3fa69de43779ecdc26df699c37387485 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2009-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8ed0374b345d6076196e14ccb5c18d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5febe17d7298c9ac4da4b017a5114ea8 |
| publicationDate | 2012-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2469039-C2 |
| titleOfInvention | Method of producing clopidogrel and derivatives thereof |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to a method of producing (S)-2-clopidogrel and salts thereof, which involves the following steps: (a) enzymatic hydrolysis of a racemic 2-chlorophenylglycine alkyl ester of formula 9 using an enzyme which is efficient for aqueous solution or aqueous phase hydrolysis to obtain an optically active compound of formula 10 ; (b) reaction of the formed optically active compound of formula 10 with a compound of formula 11 to obtain a compound of formula 12 and (c) cyclisation of the compound of formula 12 with a formulating agent in the presence of acid, where R 1 denotes H, substituted or unsubstituted C 1 -C 8 -alkyl, substituted or unsubstituted C 1 -C 8 -alkenyl, benzyl or C 3 -C 6 -cycloalkyl; and X denotes a halogen atom selected from a group consisting of fluorine (F), chlorine (Cl), bromine (Br) and iodine (I), or -OSO 2 R 2 (where R 2 denotes a substituted or unsubstituted C 1 -C 8 -alkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heteroarylalkyl). n EFFECT: novel method of producing clopidogrel which does not involve use of chiral resolving agents, which reduces the cost of preparations while maintaining high output of the product. n 7 cl, 4 ex |
| priorityDate | 2008-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 145.