abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: claimed invention relates to specific compounds of 1-substituted 3,4-tetrahydroisoquinoline derivative. Invention also relates to pharmaceutical composition based on claimed compounds, to blocker of N-type Ca 2+ - channel based on claimed compounds, to application of claimed compounds, as well as to method of prevention or treatment of some pathologic conditions. n EFFECT: obtained are novel 3,4-tetrahydroisoquinoline derivatives, having substituent in 1-position and possessing blocking action on N-type Ca 2+ - channels. n 15 cl, 129 tbl, 17 ex |