http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2464272-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3c65481ef3ea65e134804296a394571 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ae685a7e3615c023c5fb257638ff01d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-708 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-708 |
| filingDate | 2007-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccbf2de8cfda6e0b47c2fde1b2775311 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb0da325cf76c599b6aea23e59d1f931 |
| publicationDate | 2012-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2464272-C2 |
| titleOfInvention | Nucleoside aryl phosphoramidates and use thereof as anti-viral agents for treating hepatitus c virus |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to compounds of formula I with antiviral activity, which can be used in medicine , where Ar is naphthyl; T is selected from H-, F-, N 3 -, -NH 2 , -OH, C 1-3 -alkyl, C 1-3 alkyl-O-, -SH and C 1-3 alkylthio; V is selected from -OT', -H, -F and -Cl; where T is selected from -H, -CH 3 , C 1-16 alkylcarbonyl, C 2-18 alkenylcarbonyl, C 1-10 alkoxycarbonyl, C 3-6 cycloalkylcarbonyl and C 3-6 cycloalkyloxycarbonyl; T" is selected from -H, -CH 3 , C 1-16 alkylcarbonyl, C 2-18 alkenylcarbonyl, C 1-10 alkyloxycarbonyl, C 3-6 cycloalkylcarbonyl and C 3-6 cycloalkyloxycarbonyl; n equals 0 or 1, and, when n=1, X=0, when n=0, a double bond exists between position 3 and 4 and X is selected from H, OH, F, Cl, Br, I, C 1-6 alkyl and NR 5 R 6 ; R 5 and R 6 are selected from H and C 1-6 alkyl; Z is selected from H, OH, F, Cl, Br, I, C 1-6 alkyl and NR 5 R 6 ; Y is selected from H, OH, F, Cl, Br, I, C 1-6 alkyl, C 2-8 alkynyl, NR 5 R 6 ; Q is selected from O, S and CR 7 R 8 ; R 7 and R 8 are selected from H and C 1-6 alkyl; R 1 and R 2 are selected from H, C 1-20 alkyl, C 2-20 alkenyl, C 1-20 alkoxyC 6-30 alkyl, C 1-20 alkoxyC 6-30 aryl, C 2-20 alkynyl, C 6-30 aryl, C 3-20 cycloalkylC 6-30 aryl and C 5-20 heterocyclyl; R 3 and R 4 are selected from H, C 1-20 alkyl, C 2-20 alkenyl, C 1-30 alkyl, C 1-20 alkoxyC 6-30 aryl, C 2-20 alkynyl, C 6-30 aryl, C 3-20 cycloalkylC 6-30 aryl and C 5-20 heterocyclyl; R 1 and R 4 can together contain a -(CH 2 ) 3 -alkylene chain. n EFFECT: novel biologically active compounds are disclosed. n 27 cl, 9 ex, 2 tbl |
| priorityDate | 2006-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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