| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention relates to field of medicine, namely to pharmaceutical industry and deals with disulfiram preparations. Medical form of disulfiram with prolonged action contains, at least, one microsphere from disulfiram, covered with first stabilising nanosize coating from neutral polysaccharides or gelatin, enclosed in second, spatially linked coating in form of microcapsule from neutral polysaccharides. Invention also deals with method of obtaining medical form of disulfiram with prolonged action. n EFFECT: application of claimed inventions ensures durative effect of prolonged action of disulfiram, stabile kinetics of drug release into tissues, sparing procedure of drug introduction and excludes possibility of its independent removal. n 7 cl, 9 ex, 3 dwg |