| abstract |
FIELD: medicine. n SUBSTANCE: invention refers to peptides of general formula R r -AA-R 2 which can regulate neuron exocytosis, their mixtures and their cosmetically and pharmaceutically acceptable salts wherein AA represents a sequence of 6-40 neighbouring amino acids contained in the amino acid sequence of the protein SNAP-25 R 1 is specified in a group consisting of H or acetyl, or saturated or unsaturated, linear, branched or cyclic C 3 -C 24 acyl, or a polyethylene glycol polymer; R 2 is specified in a group consisting of amino, unsubstituted or substituted by saturated linear or branched, or cyclic C 2 -C 24 aliphatic groups provided when R 1 represents H or acetyl, R 2 is other tuhan unsubstituted amino. The invention also refers to cosmetic or pharmaceutical compositions containing such peptides, and use of such for treating the conditions which require regulation of neuron exocytosis, preferentially for skin treatment. n EFFECT: higher clinical effectiveness. n 12 cl, 1 dwg, 8 ex |