| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to chemical-pharmaceutical industry, particularly a technology of a new dosage form of 3,3 1 -diindolylmethane. A method consists in mixing 3,3 1 -diindolylmethane and a liquid fatty excipient and adding a wedding agent. In mixing, the prepared mixture is heated to 35-45°C to prepare a solution. Then the prepared solution is cooled to 21-23°C to fill gelatine capsules in the following proportions, g/capsule: 3,3 1 -diindolylmethane - 0.01-0.1, the liquid fatty excipient - 0.05-0.1, the wedding agent 0.4-0.45. The prepared drug in the form of soft gelatine capsules containing 3,3 1 -diindolylmethane in the form of the solution enables higher bioavailability of the active substance. n EFFECT: prepared drug is non-toxic, safe in prolonged introduction, has no local irritant action, no toxic effect on the immune and reproductive systems. n 4 cl, 4 dwg, 7 tbl, 6 ex |