http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2455292-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c731b0ac176a305e7de19e6581f35fe2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
| filingDate | 2006-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8a47e4500bdbddb09b5fadc059c7ece http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9cfe20597f0dc78faa4ad41733dac6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f55e08f522ce0af888139e7dedbe44b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e54524332a5c58cb41d54666284640a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7dc9dfa27a68f5d8a7c6f38eb9b830f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0f3fa0c9546ff36cee6f8decd34c9c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b6e931585dec17945216e9e4695e7ae |
| publicationDate | 2012-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2455292-C2 |
| titleOfInvention | Improved method of producing 4-(benzimidazolyl methylamino)-benzamides and salts thereof |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to a method of producing optionally substituted 4-(benzimidazo-2-yl methylamino)benzamidine of formula (I) in which R 1 denotes a methyl group, R 2 denotes a R 21 NR 22 group, where R 21 denotes an ethyl group which is substituted with an ethoxycarbonyl group, and R 22 denotes a pyridin-2-yl group, R 3 denotes an n-hexyloxycarbonyl group, where at step (a) phenyldiamine of formula (II) where R 1 and R 2 assume values given for formula (I), which reacts with 2-[4-(1,2,4-oxadiazol-5-on-3-yl)phenylamino]acetic acid, to obtain a product of formula (III) where R 1 and R 2 assume values given for formula (I), which is hydrogenated at temperature from 30 to 60°C at hydrogen pressure from 1 to 10 bar, over palladium on activated charcoal (Pd/C) in a mixture of tetrahydrofuran and water, and then, without any preliminary extraction of the hydrogenation product, the obtained compound of formula (I), in which R 3 denotes hydrogen, in the presence of potassium carbonate reacts with a compound of formula (IV) R 3 -X (IV), where R 3 assumes values given for formula (I), and X denotes a suitable splitting group. n EFFECT: simple method of producing optionally substituted 4-(benzimidazo-2-yl methylamino)benzamidine. n 3 cl, 9 ex |
| priorityDate | 2005-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.