| abstract |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to acyclic substituted furopyrimidine derivatives of formula wherein A means O, L means (C1-C7)-alkanediyl, (C2-C7)-alkenediyl or a group of formula *-L1-Q-L2, wherein * means an attachment point to the group CHR3, L1 means (C1-C5)-alanediyl1 which can be substituted by (C1-C3)-alkyl or (C1-C4)-alkoxy, L2 means a bond or (C1-C3)-alkanediyl, and Q means O or N-R6 wherein R6 means hydrogen or (C1-C6)-alkyl, Z means a group of formula wherein # means an attachment point to the group L and R7 means hydrogen or (C1-C3)-O-alkyl, R1 and R2 independently represent a substitute specified among: halogens, (C1-C6)-alkyl, (C1-C6)-alkenyl, (C1-C6)-alkoxy, trifluoromethyl, trifluoromethoxy, (C1-C6)-alkylthio, amino, mono-(C1-C6)-alkylamino and di-(C1-C6)-alkylamino) and (C1-C6)-alkyl for its part can be substituted by cyano, or two residues R2 coupled with carbon neighbours of a phenyl ring, together forms a group of formulas -O-CH2-O-, n and o independently means 0, 1 or 2; if R1 or R2 are found more than once, their values can be equal or different, R3 means hydrogen or (C1-C4)-alkyl, and R4 means hydrogen, as well as to their salts, solvates and salt solvates. The invention also concerns a method for preparing said compounds. ^ EFFECT: there are produced new compounds which can find application in medicine for preparing drugs for treating and/or preventing diseases, particularly for treating and/or preventing cardiovascular diseases. ^ 7 cl, 1 tbl, 160 ex |