| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to novel crystalline forms of tiotropium bromide, characterised by X-ray powder diffraction pattern XRD, having peaks at approximately 20.2, 26.5, 28.0 and 31.2±0.2 degrees 2-theta and at approximately 20.9, 21.1, 21.4 and 34.43±0.2 degrees 2-theta. The invention also relates to methods of producing said forms and pharmaceutical compositions having anticholinergic activity, based on said compounds. n EFFECT: novel more stable forms of tiotropium bromide which can be used in medicine to treat asthma or chronic obstructive pulmonary disease are obtained. n 22 cl, 16 dwg, 21 ex |