| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to novel substituted cyclohexylmethyl derivatives, having serotonin, noradrenaline or opioid receptor inhibiting activity, optionally in form of cis- or trans-diastereomers or mixture thereof in form of bases or salts with physiologically compatible acids. In formula (1): R 2 denotes H or OH; R 1 and R 2 together denote or =N-OH, R 3 denotes a phenyl residue which is unsubstituted or monosubstituted with a halogen atom or a heteroaryl residue selected from a five-member sulphur-containing heteroaryl such as a thienyl residue or an unsubstituted phenyl residue bonded through a C 1 -C 4 alkyl group, R 4 and R 5 independently denote an unsubstituted C 1 -C 3 alkyl or R 4 and R 5 together denote (CH 2 ) 3-6 , R 8 denotes a linear saturated C 1 -C 4 alkyl group bonded with an aryl, which is unsubstituted or monosubstituted with halogen atoms, R 9 denotes a saturated C 1 -C 8 alkyl; values of radicals R 1 , m, n, R 6 , R 7 , R 10 -R 13 are given in the claim. The invention also relates to methods of producing compounds of formula (I), a medicinal agent containing said compounds, use of compounds of formula (I) to prepare a medicinal agent for anaesthetic treatment during sharp, neuropathic or chronic pain and for treating depression, urinary incontinence, diarrhoea and alcoholism. n EFFECT: high efficiency of using the compounds. n 32 cl, 501 ex, 21 tbl |