| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to new derivatives of 5-substituted camptothecin of formula 1 wherein R represents F, R1 represents hydrogen; R2 represents hydrogen; and R3 represents hydrogen; its pharmaceutically acceptable salts, diastereoisomers and appropriate mixtures which show anticancer activity. n EFFECT: invention refers to a method for preparing of these compounds, using them as anticancer drugs, and to pharmaceutical compositions containing them. n 6 cl, 2 tbl, 22 ex |