| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention relates to novel derivatives of 1,3-dihydro-5-isobenzofurancarbonyl of formula 1, or their pharmaceutically acceptable salts, where R 1 represents phenyl, phenyl substituted with C 1 -C 6 -alkyloxy, phenyl, substituted with C 1 -C 6 -alkyl, phenyl, substituted with C 1 -C 6 -dialkylamine, phenyl, substituted with halogen or thienyl; R 2 is selected from group consisting of C 1 -C 6 -dialkylamino, pyrazolyl and imidazolyl, excluding C 1 -C 6 -dialkylamino, if R 1 represents phenyl, phenyl substituted with halogen; n represents integer number from 1 to 3, and method of their obtaining. n EFFECT: invention also relates to pharmaceutical compositions, which include formula 1 compound, and method of treatment and prevention of premature ejaculation. n 18 cl, 8 tbl, 68 ex |