| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to new compounds of formula , wherein: R 1 means phenyl, 6-member heteroaryl containing one or two atoms N as heteroatoms and wherein said phenyl, 6-member heteroaryl is optionally substituted by one R 7 ; R 2 means phenyl, 6-member heteroaryl containing one or two atoms N as heteroatoms and wherein each of said phenyl or 6-member heteroaryl is optionally substituted by one R 7 ; R 3 means halogen R 7 independently means halogen, OR 8 , phenyl, 6-member heteroaryl containing one or two atoms N as heteroatoms wherein any phenyl or heteroaryl can be optionally substituted by one R 14 ; R 14 means halogen, OR 8 ; R 8 independently means C 1-6 alkyl; m is equal to 1; in the form of a free base or its pharmaceutically acceptable salt, and to their pharmaceutically acceptable salt. n EFFECT: compounds possess BACE inhibitory activity. n 8 cl, 6 tbl, 136 ex |