| abstract |
FIELD: chemistry. n SUBSTANCE: present invention relates to a method of producing (-)-beta-elemenal, use of (-)-beta-elemenal as an antitumour agent, as well as to a pharmaceutical composition and a medicinal agent based on said compound. The method involves reaction of a mixture of isomeric beta-elemenols (2:1) with c MnO 2 , activated in a vacuum at 150°C as a catalyst. The initial mixture of isomeric beta-elemenols (2:1) is obtained by reacting a mixture of diastereomeric epoxides (2:1) with diisopropylamine in the presence of n-BuLi. n EFFECT: higher efficiency. n 4 cl, 21 tbl, 9 dwg, 36 ex |