http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2444512-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8313c1fb6eab4f679f2b3bc44883f69 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-10 |
| filingDate | 2010-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9cd5e7556f74efac6f0c4eb8515c060 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5818c1fe1179922fc86edaab851f4ae2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ce40f22222d4310f283edc630078a7c |
| publicationDate | 2012-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2444512-C1 |
| titleOfInvention | Method of producing 2,7-bis[2-(diethyamino)ethoxy]-fluorenone-9 dihydrochloride |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to an improved method of producing 2,7-bis-[2-(diethylamino)ethoxy]-fluorenone-9 dihydrochloride, having immunomodulating properties and a wide range of antiviral action. The method of producing 2,7-bis-[2-(diethylamino)ethoxy]-fluorenone-9 dihydrochloride involves sulphonation of fluorene, oxidative hydroxylation of a disodium salt of 2,7- fluorene disulphonic acid, cyclisation of 4,4'-dihydroxydiphenyl-2-carboxylic acid, alkylation of 2,7-dihydroxyfluorenone with treatment of the obtained alkylated product with concentrated hydrochloric acid. The obtained product undergoes solvent refining through re-extraction of the alkylated product in an aqueous solution treated with hydrochloric acid to obtain a chloride salt of 2,7-bis-[2-(diethylamino)ethoxy]-fluorenone-9, from which nonpolar impurities are washed off using toluene solution and after treatment with alkali, the obtained phases are separated with extraction of 2,7-bis-[2-(diethylamino)ethoxy]-fluorenone-9 into an organic phase. The latter is washed with water in order to remove polar impurities and the product is converted to a chloride salt by treatment with concentrated hydrochloric acid in molar ratio 1:3.5-1:4. Said extraction steps can be carried 1-3 times. n EFFECT: method enables to cut the number of process operations at the purification step, cut solvent consumption and obtain a high-quality product with 99,85-99,90% content of basic substance. n 1 tbl, 1 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2521595-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2707176-C1 |
| priorityDate | 2010-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.