http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2441651-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33dd4375bd91cdd6667025e01584dbad http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b581e31c4a2e19c905c70c89d049f30a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5513 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 |
| filingDate | 2010-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a51f2d50780ba4c797dbd9c9ae9a3fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86119fbc7045cf502ed5f694cd09789a |
| publicationDate | 2012-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2441651-C1 |
| titleOfInvention | Method for production of clozapine pharmaceutical composition in form of tablets and pharmaceutical composition |
| abstract | FIELD: medicine, pharmacy. n SUBSTANCE: invention refers to the field of medicine and pharmacy and refers to the method of production of tableted pharmaceutical form of clozapine (8-Chlorine-11 -(4-methylpiperasine-1-yl)-5H-dibenso [b, e][1, 4] diazepine). The essence of method is pre-produced dry mixture of lactose, potato starch and clozapine is hydrated by 10% water solution of Collidon 25, wet granulation is performed, and then drying is performed at temperature 45-50°C. Resulting granules are subject to dry granulation until the productions of granules with average diameter 1.0-1.5 mm, powdered with aerosil and stearic acid and/or its salt. The resulting mixture is pelletized and the tablets are produced with the following mixture ratio,%: n n n n n n n Clozapine n 23-42 n n Lactose n 47-52 n n Potato starch n 10-20 n n Collidon 25 n 4-5 n n Aerosil n 1-2 n n Stearic acid n 1-2 n n n n n n n n n n n n n n EFFECT: production of clozapine pharmaceutical composition in form of tablets. n 2 cl, 5 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2778448-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108619103-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017142438-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-035980-B1 |
| priorityDate | 2010-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 91.