| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: group of inventions relates to field of medicine and deals with therapeutic vaccine. Essence of the invention includes antigenic structure which contains fragment of antigenic Aβ peptide, reconstructed in liposome, which consists of occurring once or several times repeated section, which includes from 13 to 15 adjacent amino acid residues from N-end 1-16 or 1-17-fragment of Aβ peptide, selected from group, including residues 1-15, 1-14 and 1-13, and is modified by means of lipophilic or hydrophobic fragment, which facilitates imbedding into lipid bilayer of liposome. Invention also includes therapeutic vaccine composition, method of obtaining vaccine composition, method of therapeutic vaccine composition application for preparation of medication and antibody, which are obtained from animal organism after immunisation with therapeutic vaccine. Group of inventions is intended for therapeutic application in treatment of diseases and disorders which are induced or associated with amyloid or amyloid-like proteins, including amyloidosis. n EFFECT: creation of highly specific immune response. n 49 cl, 12 ex, 4 tbl, 2 dwg |