| abstract |
FIELD: chemistry. n SUBSTANCE: method is realised by treating a compound of formula n n n n with boronic acid or ether thereof of formula n , n in which two OR 15 groups together with the boron atom with which they are bonded form a pinacolato boronate ester group in the presence of a Pd catalyst. The invention relates to a method of producing a pharmaceutically acceptable salt of thieno[3,2-d]pyrimidine of formula n . n The invention also relates to a pharmaceutical composition, having phosphatidyl inositol-3-kinase inhibitor activity, containing thieno[3,2-d]pyrimidine of formula (I) as an active ingredient, a method of preparing said composition and use of thieno[3,2-d]pyrimidine of formula (I) or pharmaceutically acceptable salt thereof in producing a medicinal agent for inhibiting phosphatidyl inositol-3-kinase. n EFFECT: use of the derivative as a phosphatidyl inositol-3-kinase inhibitor. n 11 cl, 13 ex |