http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2439057-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bf03672ef18280dca3bdeae0441388de |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-08 |
| filingDate | 2006-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c46902aab0d4b34fae52ce3bff1692e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db0cddab4fb21c0e514b20d1b110eac8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ed327658d516cccc1ab39a1eb4cf0c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_206cf1bcfc99b23b06a3d90be60ae836 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd9106e9799287be2bfc3e8bb1a59796 |
| publicationDate | 2012-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2439057-C2 |
| titleOfInvention | Method of obtaining antiemetic medication |
| abstract | FIELD: medicine, pharmaceutics. n SUBSTANCE: claimed invention relates to method of obtaining optically pure antiemetic medication, R-(+)-ondansetron, which includes the following stages: a) processing of ondansetron hydrochloride with base, which is selected from group, containing metal hydroxide and carbonate or bicarbonate; b) processing of free ondansetron base with R/S-(+)-n-toluyl tartrate acid in mixture of dimethylforamide and water obtaining salt of 3-R/S-ondansetron-n-toluene tartrate acid; c) fractional recrystallisation of salt of 3-R/S- ondansetron-n-di-toluene tartrate acid from mixture of dimethylformamide and water, if necessary, in presence of primer obtaining salt of 3-R-(+)- ondansetron-n-di-toluene tartrate acid of required enantiomer purity; and processing by base with obtaining free base of 3-R-(+)- ondansetron, and at first ondansetron salt is dissolved in water at room temperatute, after which dimethylformamide is added to solution, with further heating of mixture to 80-85°C, cooling to 60°C and filtration at that temperature, ratio of water and dimethylformamide volume in mixture constituting 2:1; d) processing of free base of R-(+)-ondansetron with hydrochloric acid in presence of alcohol as solvent obtaining 3-R-(+)-ondansetron hydrochloride. n EFFECT: claimed method is less time-consuming and ensures higher product purity in comparison with known methods-analogues. n 4 cl, 9 ex |
| priorityDate | 2006-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.