| abstract |
FIELD: chemistry. n SUBSTANCE: invention describes novel macrocyclic compounds of formulae pharmaceutically acceptable salts or stereoisomers thereof, where R 1 = -OR 5 , -NH-SO 2 R 6 ; R 2 = hydrogen; R 3 = C 1-6 -alkyl; R 4 = isoquinolinyl, possibly substituted; n equals 4 or 5; R 5 = hydrogen; R 6 = C 3-7 -cycloalkyl, and a pharmaceutical composition containing said compounds. n EFFECT: novel compounds have hepatitis C virus replication inhibitory action and can be used in medicine. n 6 cl, 32 ex, 1 tbl |