| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a compound of general formula or pharmaceutically acceptable salt thereof, where each of W 1 and W 2 independently denotes CH; X denotes NR 5 or CR 6 R 7 , where R 5 is hydrogen, C 1-8 alkyl, and each of R 6 and R 7 is independently hydrogen; Y denotes -(CR 8 R 9 ) n -, where each of R 8 and R 9 independently denotes hydrogen or C 1-8 alkyl, and n is a number from 1 to 4; or X and Y together form -CR 10 =CR 11 -, where each of R 10 and R 11 independently denotes hydrogen; Z is carboxyl; G denotes O, S or CR 12 R 13 , where each of R 12 and R 13 independently denotes hydrogen; A denotes a 5-member heterocyclic ring selected from a group consisting of thiazole, oxazole and thiophene, in which the heterocyclic ring is optionally substituted with C 1-8 alkyl; B denotes a C 1-8 alkylene or C 2-8 alkenylene chain; each of R 1 and R 2 independently denotes hydrogen, C 1-8 alkyl, halogen, C 1-8 alkyl substituted with halogen, or hydroxyl; each of R 3 and R 4 independently denotes hydrogen or C 1-8 alkyl; and m is equal to 0. n EFFECT: compounds of formula (I) act as peroxisome proliferator-activated receptor δ activators. n 23 cl, 39 tbl, 14 ex |