| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to C-phenyl-1-thioglucitols of formula (I), [formula I] , where X is a hydrogen atom or a C 1-6 alkyl group, Y is a C 1-6 alkylene group or -O-(CH 2 ) n - (where n equals a integer from 1 to 5), and Z is -CONHR A or -NHCONHR B (provided that when Z is -NHCONHR B , n is not equal to 1), where R A is a C 1-6 alkyl group substituted with 1-3 substitutes selected from a group consisting of a hydroxyl group and -CONH 2 , and R B denotes a hydrogen atom or a C 1-6 alkyl group substituted with 1-3 substitutes selected from a group consisting of a hydroxyl group and -CONH 2 , and pharmaceutically acceptable salts thereof or hydrates thereof. The invention also relates to a sodium-dependent glucose transporter 1 (SGLT1) activity inhibitor, a sodium-dependent glucose transporter 1 (SGLT1) and sodium-dependent glucose transporter 2 (SGLT2) activity inhibitor, as well as a prophylactic or therapeutic agent against diabetes. n EFFECT: obtaining novel biologically active compounds which are sodium-dependent glucose transporter 1 and sodium-dependent glucose transporter 2 activity inhibitors. n 5 cl, 11 ex, 4 tbl |