http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2434847-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_447e7571e384c8b9c4fd3f6c875eea51 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-083 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-30 |
| filingDate | 2006-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cd2fe5ab5281179ef1ad42b9d69f861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7577100592d1ec2976c82906902ed437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_742c88b006e350207e43f6682b87647d |
| publicationDate | 2011-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2434847-C2 |
| titleOfInvention | Method for asymmetric alkynylation of alpha-iminoesters |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to a method of producing enantiomeric excess of asymmetrically alkynylated α-aminoesters of formula (III) in which R 1 and R 2 independently denote C 1-7 -alkyl, optionally substituted with phenyl or trimethylsilyl, or C 3-5 -cycloalkyl; Y denotes H or a nitrogen atom protecting group. The method involves reaction of α-iminoester of formula (I), in which R 1 and Y assume values given for formula III, with an alkyl containing a terminal triple bond, of formula (II), in which R 2 assumes values given for formula III, in the presence of a catalyst. The catalyst used contains a transition metal complex CuPF 6 ·4MeCN or CuOTf·0.5C 6 H 6 and a chiral ligand selected from , enantiomers thereof and mixture of enantiomers thereof. n EFFECT: method provides high output of asymmetrically alkynylated α-aminoesters of formula (III), which can be used in synthesis as optically active derivatives of amino acids which do not occur naturally. n 3 cl, 3 tbl, 4 ex |
| priorityDate | 2005-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.