| abstract |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to pharmaceutical industry, in particular to pharmaceutical compositions and dosed forms, which include granules with regulated in time pulse release (RTpR), where said granules with RTpR include solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-increasing polymer, and RTpR- coating, which contains water-insoluble polymer and enterosoluble polymer, where active pharmaceutical ingredient includes weak-base active pharmaceutical ingredient, which has solubility not higher than 100 mcg/ml at pH 6.8. ^ EFFECT: increase of medication delivery efficiency. ^ 25 cl, 10 ex, 12 dwg, 2 tbl |