http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2434010-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c816365ca2cedee5cee1ff2558064e8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 |
| filingDate | 2008-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdeb3dcbb33000285e92ac1f71fa753a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b329172a9c40c6995ba0c71c48b5896 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7168a6e1a7499d0dcdf6d35ae143897d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5393b797abba03d37a4afb9b055179eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e31463f5f16b7391455adcf3d301e9a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b969a63a638c0d95c3475bcd855f7090 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6267daa78f747ab4b8d3fd5d1b6b5e16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c010db4340c105631cf961524fe10eb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75995d37fd352624988d080812c2c2a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe1a84154d9eee80d2b5201a3ffbb084 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1c8e31b725d4ed3fffe5d23bdd0c277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1759249ed5d84a5339656295e35230a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4aeeb20681a1068f1bba6fecc7c28a79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f53ce66a1daed442a0aebe1329afd81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d82c314e96ec9f239447b75515b619f |
| publicationDate | 2011-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2434010-C2 |
| titleOfInvention | Novel amide derivative for inhibiting growth of cancer cells |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to novel amide derivatives of formula (I), isomers and pharmaceutically acceptable salt thereof, which have cancer cell selective inhibiting properties, caused by an epidermal growth factor receptor (EGFR), selected from EGFR or caused by EGFR mutation. In formula (I): (I) (a) or (b), A denotes a group (a) or (b), R 4 , R 5 , R 6 and R 7 , each independently denote hydrogen, halogen, N-C 1 - 6 alkyl or N-hydroxyamido or inverse C-C 1-6 alkylamido (-NHCOC 1-6 alkyl), hydroxycarbonyl(-COOH), C 1-6 alkyloxycarbonyl(-COOC 1-6 ), C 1-6 alkyl or C 1-6 alkyl, substituted with a hydroxy group, C 1-6 dialkylamino or a saturated 5-6-member heterocyclic group with 1-2 heteroatoms and selected from nitrogen and oxygen atoms; R 1 denotes a phenyl or a 6-member heteroaryl group with a nitrogen atom as a heteroatom, each of which is substituted with 1-3 X, or C 1-6 alkyl, substituted with a phenyl, which can be substituted with halogen atoms; R 2 denotes hydrogen, hydroxy, C 1-6 alkoxy or C 1-6 alkoxy, substituted C 1-6 alkoxy or 5-6-member saturated heterocyclic group; R 3 denotes hydrogen, -COOH, C 1-6 alkyloxycarbonyl or amido, N-unsubstituted or N-substituted Y; n a and n b each is a whole number ranging from 1 to 3; where: X denotes hydrogen, halogen, hydroxy, cyano, nitro, (mono-, di- or trihalogen)methyl, mercapto, C 1-6 alkylthio, acrylamido, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, phenyloxy, C 1-6 dialkylamino or C 1-6 alkyl or C 1-6 alkoxy, substituted with Z, provided that when the number of substitutes X equals two or more, groups X can be condensed with each other to form a 5-member cyclic structure, possibly containing 2 nitrogen atoms in the ring as heteroatoms; Y denotes hydroxy, C 1-6 alkyl or C 1-6 alkyl substituted with Z, C 1-6 alkyl has 1-4 fragments selected from a group consisting of N, O, S, SO and SO 2 ; and Z denotes C 1-6 alkyl, phenyl or a 6-member heterocyclic group containing one or more heteroatoms selected from N or O. Said phenyl or heterocyclic group is unsubstituted or substituted with a halogen. n EFFECT: improved properties of the derivatives. n 4 cl, 7 tbl, 144 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2671843-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2769694-C2 |
| priorityDate | 2007-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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