| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: pharmaceutical composition of prolonged release in form of pill includes metformin or its pharmaceutically acceptable salt; agent, which generates gas, selected from carbonates or bicarbonates; hydrophilic or hydrophobic polymer as release moderator; disintegration-causing agent; hydrophilic polymer for ensuring system stability; additional hydrophilic polymer or gum as release moderator, binding substance and other pharmaceutical additional substances. n EFFECT: composition by invention ensures increased term of device holding in stomach and release of metformin by regulated method, in addition, it is simple and cheap in production. n 19 cl, 1 dwg, 11 tbl, 8 ex |