| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: present invention refers to new polysaccharide protein derivatives, particularly insulin where polysaccharide is polysialic acid containing 20 to 125 units of sialic acid and where at least 85 % of insulin derivatives are modified on a N-tail of insulin B-chain only, and also to methods of producing it. n EFFECT: invention provides higher stability, prolonged biological half-life, lower insulin immunogenicity, and can find application in pharmaceutical compositions for diabetes treatment. n 3 tbl, 15 dwg |