| abstract |
FIELD: chemistry. n SUBSTANCE: disclosed an analogue of 17-desmethylrapamycin, having a structure described in the claim, or a pharmaceutically acceptable derivative thereof. The invention also relates to methods of producing and extracting 17-desmethylrapamycin analogue. 17-desmethylrapamycin analogues are used in preparing medicine for treating cancer. The invention also discloses a pharmaceutical composition based on 17-desmethylrapamycin analogues for treating cancer and autoimmune disorders. n EFFECT: compounds are more stable in a solution, more resistant to metabolic attack and have higher bioavailability. n 25 cl, 8 dwg, 8 tbl, 11 ex |