http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2430740-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30 |
| filingDate | 2007-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_425f9045bb745ee0d64a97842c18b0b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b2eb23a6abaa8e493aec558ff4191a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e49907fd63b2389aba006c84bc8e552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c31e1be32d3f16df3dd39c9e8978b0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b51c3a119950033980cf5c0affafa63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d9933d0c8363286964a7d895904b1b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f270064510ca6d66b6c5f329cc043f29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb1fb347d4428e55f75959cc82cead8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd787ecf9cb5aa9352ba0b6baea07d84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_353a64abdc0a5ced101e60e8c705f594 |
| publicationDate | 2011-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2430740-C2 |
| titleOfInvention | Polyconjugates for polynucleotide introduction in vivo |
| abstract | FIELD: medicine, pharmaceutics. n SUBSTANCE: present invention refers to compositions which can be applied to introduce polynucleotides or other molecules which are not characterised by ability to penetrate into cells of mammal molecules. The offered composition intended for molecule introduction in a cell, contains a conjugate of formula: N-L 1 -P-(L 2 -M) y in which N means a molecule not characterised by ability to penetrate through membranes or a molecule having low ability to penetrate through the membrane; L 1 means a first reversible bond containing a bond labile in a physiological environment; P means a polymer exhibiting activity on the membrane; L 2 means a second reversible bond containing an orthogonal bond labile in the physiological environment; M means a masking agent selected from the group including steric stabilisers transferring the group directly, and charge-modifying agents, and y means an integer exceeding 0. n EFFECT: polyconjugate systems are characterised by types of activity which provide the directed transfer, exhibit antiopsonising, antiaggregation and transfection action, in small biocompatible carriers intended for introduction in vivo. n 18 cl, 26 ex, 36 dwg |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2619453-C2 |
| priorityDate | 2006-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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