| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to novel compounds of formula n , n where: X is a nitrogen or carbon atom; Ar is phenyl or a heteroaromatic ring selected from pyrazolyl, furanyl, thiophenyl and isoxazolyl; R 1 is hydrogen, halogen, CN or (C 1 -C 4 )alkyl; R 2 is halogen or (C 1 -C 3 )alkoxy optionally fluorinated with 1-3 fluorine atoms; R 3 and R 5 independently denote hydrogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkenyl or hydroxymethyl; R 4 is hydrogen, halogen, optionally fluorinated (C 1 -C 4 )alkoxy or aryl(C 1 -C 4 )alkoxy; R 6 is hydrogen, optionally fluorinated (C 1 -C 4 )alkyl; each R 7 independenlty denotes hydrogen, halogen, optionally fluorinated (C 1 -C 4 )alkyl or (C 1 -C 4 )alkoxy optionally fluorinated with 1-3 fluorine atoms; or pharmaceutically acceptable acid addition salts thereof. The invention also relates to use of compounds of formula (I) in a pharmaceutical composition and when preparing a medicinal agent meant for treatment, the aim of which is to change the secondary signal activity level after activation of glucocorticoid receptors. n EFFECT: compounds of formula I for changing the secondary signal activity level after activation of glucocorticoid receptors. n 7 cl, 5 dwg, 49 ex |