| abstract |
FIELD: medicine. n SUBSTANCE: extremity ischemia is modelled by removing a portion of a great vessel, including with simultaneous additional modelling of nitrogen oxide (NO) deficiency by intraperitoneal introduction of a NO synthesis blocker N-nitro-L-arginine of methyl ester (L-NAME) 25 mg/kg daily for 7 days. In both cases, the ischemia is corrected by subcutaneous introduction of recombinant erythropoein 50 IU/kg for the first, third and fifth days of experiment. n EFFECT: effective ischemia treatment in experiment ensured by improved extremity microcirculation. n 1 ex, 1 tbl |