http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2426121-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17dc2276ea948da5bb33aba94d29e30f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48 |
| filingDate | 2010-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33b6cf30dc039594874e9f46fd98ec9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb826049a04956d30856ea6b87646eb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6cb8fae799accc952e4827436f351a5 |
| publicationDate | 2011-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2426121-C1 |
| titleOfInvention | Method of evaluating cyclosporine concentration in patients' blood |
| abstract | FIELD: medicine. n SUBSTANCE: there is described a method of quantitative cyclosporine A evaluation in patients' blood involving blood protein precipitation by adding an aqueous solution of zinc sulphate and methanol, mixing, centrifuging and sampling a centrifugate; separating the centrifugate ingredients by reverse phase high-yield liquid chromatography, mass-spectrometre detecting cyclosporine A and evaluating the cyclosporine A concentration with plotting a calibration curve; blood protein are precipitated with using whole blood; blood protein precipitation is followed by additional salt impurity precipitation by adding methanol to the centrifugate to the general concentration not less than 90 vol. %, mixing again, centrifuging and sampling the centrifugate; separating the centrifugate ingredients, detecting and evaluating the cyclosporine A concentration. n EFFECT: method allows facilitating analysis simplicity and universality with providing adequate sensitivity and selectivity ensured by the absence of necessity for the internal standard and online extraction and lower requirements to specification of the used mass spectrometre by conducting preliminary impurity precipitation. n 1 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2506900-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114636772-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2637430-C1 |
| priorityDate | 2010-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.