http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2425149-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc41c793ced4f36a616b5a8a71032be1 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-06 |
| filingDate | 2010-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da92c39dba6339d96cd4784058e9e333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fee173da6c7a9edb32ccc65a828d79ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ddd4318769a4cadd6c61fcafe5f21ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72778081831bd5141a289a0d32e67abf |
| publicationDate | 2011-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2425149-C1 |
| titleOfInvention | Method of cell selection in vivo by using lysomustine |
| abstract | FIELD: medicine. n SUBSTANCE: one or more genetic makers containing a gene of a MGMT enzyme mutant form (O6-methylguanine DNA-methyltransferase) resistant to O6-benzylguanine inhibitor inhibiting action of a MGMT natural form, and also a nucleotide sequence exhibiting therapeutic action are introduced into cells. The cells modified in such a way are transplanted into a body, thereafter said inhibitor, and then lysomustine isomer 2 or mixed lysomustine isomers 1 and 2 which inhibit autologous cell reproduction thereby inducing modified cell selection are introduced in the body. n EFFECT: invention provides more effective selection of the modified cells and allows higher safety and efficiency of the method of cell selection ensured by using lysomustine characterised by lower toxicity. n 4 cl, 9 dwg, 1 ex |
| priorityDate | 2010-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 185.