http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2424241-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d931a9341bfd26bc7f1d934dc0984396 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b159fc011c606611e8a6b85fde615dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_010dd7f8f8fe9395c4784ee34957c9b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fa271038f301ac4f187f57f32ca9d5c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 |
| filingDate | 2008-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52cedf89079e9d05cc4546c83bfff9c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed9cf0f7e36bf2262a7503ac290021a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_609f085c7401009008f8299929839b77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5c678748f3868a660a289d606bb2d23 |
| publicationDate | 2011-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2424241-C2 |
| titleOfInvention | Xanthine derivatives, having antiproliferative activity, cell differentiation modulators, method of slowing down tumour cell proliferation, method of inducing differentiation in cells |
| abstract | FIELD: chemistry. n SUBSTANCE: disclosed agent is a xanthine derivative of formula 1 n , where R 1 denotes CH 3 , R 2 denotes CH 3 ; R 3 denotes halogens: F,Cl, Br, I; R 4 denotes hydrogen; R 1 denotes CH 3 , R 2 denotes CH 3 ; R 3 denotes hydrogen, halogens: F, Cl, Br, I; R 4 denotes CH 2 COOH; R 1 denotes hydrogen, R 2 denotes CH 3 ; R 3 denotes halogens: F, Cl, Br, I; R 4 denotes CH 3 . The preferred compounds of the said agent are 8-chlorotheophylline, 8-bromotheophylline and theophylline-7-acetate. The invention also relates to a method of slowing down proliferation of tumour cells and a method of inducing differentiation in mouse melanoma B16-F10 cells. Each of the methods involves addition of an effective amount of the said agent in an effective amount, preferably in amount of 1 mM. n EFFECT: improved properties of the derivatives. n 8 cl, 4 tbl, 12 dwg |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2615908-C1 |
| priorityDate | 2008-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.