http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2421442-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76b6305c90835afa958bb677347f6fbe |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-813 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-45 |
| filingDate | 2010-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e66ac91ba26593295d27e4f661eedc2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14f274fe92a5161d9a72584d99883b26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82ee7d33918853b007b6b74ceac87eb5 |
| publicationDate | 2011-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2421442-C1 |
| titleOfInvention | Method of producing fluorine-containing tetraketones |
| abstract | FIELD: chemistry. n SUBSTANCE: present invention relates to a method of producing fluorine-containing tetraketones of general formula: , where I) R 1 =CHCH(CH 3 ) 2 ; R 2 =CH 3 ; II)R 1 =CH 2 ; R 2 =Ph III) R 1 =CHCH 2 CH 3 ; R 2 =Ph, which can be used as synthons for producing their fluorine-containing aza- and thio-analogues, β-hydroxyketones, pyrazoles, isoxazoles, as well as biologically active substances. The method involves reacting a diester of perfluoro-dicarboxylic acid with an alkylketone in the presence of sodium hydride in the medium of an organic solvent. The diester of perfluoro-dicarboxylic acid used is dimethyl ester of perfluoro-dodecane dicarboxylic acid and the alkylketone used is: acetophenone, methyl isobutyl ketone or propyl phenyl ketone, and the process is carried out in the presence of a catalyst - dibenzo-24-crown-8 ester, in molar ratio diester of perfluoro-dicarboxylic acid: alkylketone: sodium hydride: catalyst equal to 1 : (2-3.5) : 1 : (0.00025-0.0005). n EFFECT: method enables to obtain desired products with high output in a single step. n 1 tbl, 3 ex |
| priorityDate | 2010-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.