| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to novel pyrrole derivatives of the formula I: , where R 1 and R 2 independently denote Ph; mono- or disubstituted in different positions of the ring Ph, where substitute denotes -OCH 3 ; C5-heteroaryl with one heteroatom selected from O or S; R 2 denotes H, NO 2 , NH 2 , C(O)NH 2 ; R 4 denotes H, a straight or branched C1-C6-alkyl; n equals the number of methylene groups and is between 1 and 8 inclusively; X denotes O, S, NH; Y NH, -CH 2 -; Z denotes O, S; W denotes -OH, hydroxylamine, hydrazine, alkylhydrazine. n EFFECT: compounds can inhibit histone deacetylase, which enables their use in cancer treatment. n 10 cl, 9 dwg, 18 ex |