http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2413728-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcb9d01fd62b1e674a35774cacc7df5f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 2005-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6aef9e473dfaa4816dade32ff8c8e3fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afb0bb2af1fe513336f8d0cfcc5949f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48f4d560cc292690e51177165ea7b677 |
| publicationDate | 2011-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2413728-C2 |
| titleOfInvention | Method of producing r-(-)- sertaconazole mononitrate and polyacetonate of r-(-)-sertaconazole mononitrate |
| abstract | FIELD: chemistry. n SUBSTANCE: present invention relates to a method of producing (R)-(-)-sertaconazole mononitrate, in which first, a chemical reaction takes place between (R)-(-)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanol and an intermediate of general formula where L denotes a leaving group, in the presence of an interphase catalyst and a base in a medium consisting of water and a water-immiscible solvent; followed by treatment with nitric acid and recrystallisation of the solid product formed from a suitable solvent which contains a mixture of an alcohol containing 1-4 carbon atoms and acetone; the formed polyacetone of R-(-)-sertaconazole mononitrate is converted to R-(-)-sertaconazole mononitrate by drying at temperature between 80 and 90°C; and the obtained R-(-)-sertaconazole mononitrate (V) is purified. The invention also relates to polyacetonate of R-(-)-sertaconazole mononitrate . n EFFECT: novel interphase process of producing R-(-)-sertaconazole mononitrate (V). n 24 cl, 1 dwg, 1 tbl, 2 ex |
| priorityDate | 2004-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 143.