| abstract |
FIELD: medicine. ^ SUBSTANCE: invention relates to biotechnology and represents method of inhibiting or neutralisation of induction or secretion of HAS2, HA, CD44 or RHAMM by native polypeptide of domain 1 WISP-1 of humans in mammalian cells of, at least, one type. Also, by means of said polypeptide realised is method of treating various types of cancer in mammals and method of inhibiting cancer cell mobility. Invention also relates to application of polypeptide of domain 1 WISP 1 in production of medications for inhibition or neutralisation of induction or secretion of HAS2, HA, CD44 and RHAMM, for inhibiting cancer cells mobility, as well as for cancer treatment. ^ EFFECT: invention can be efficiently used in prevention and treatment of various types of cancer. ^ 25 cl, 96 dwg, 1 tbl, 29 ex |