http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2409554-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d361ae2ba137d9f3eafacd044980371c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-06 |
| filingDate | 2009-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_020ff5f78abacb5515d71ecd20eca32f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d43574ca744708ccef9033f43a56168a |
| publicationDate | 2011-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2409554-C1 |
| titleOfInvention | Method for synthesis of 4-(3,4-diaminophenoxy)benzoic acid |
| abstract | FIELD: chemistry. ^ SUBSTANCE: invention relates to an improved method for synthesis of 4-(3,4-diaminophenoxy)benzoic acid, which is used as an intermediate product in synthesis of thermally stable polymer materials. The desired compound is obtained through acylation of 2-nitro-5-chloroaniline with acetic anhydride, nucleophilic substitution of the chlorine atom during reaction with 4-hydroxybenzoic acid in DMSO in the presence of K2CO3, removal the acyl protection of the amine group as a result alkaline hydrolysis, simultaneous reduction and formation of an ester bond of 4-(3-amino-4-nitrophenoxy)benzoic acid. Acylation of 2-nitro-5-chloroaniline is carried out at temperature 90C for 1 hour and molar ratio of 2-nitro-5-chloroaniline: acetic anhydride = 1:2. Nucleophilic substitution of the chlorine atom is carried out in 8 hours at temperature 105C and molar ratio of N-acetyl-5-chloro-2-nitrianiline: 4-hydroxybenzoic acid = 1:1.05.Removal of the acyl protection is carried out in 0.5 hours at temperature 60C in 20% aqueous solution of KOH. Reduction is carried out using a solution of SnCl22H2O in concentrated hydrochloric acid at temperature 90C for 1 hour and molar ratio 4-(3-amino-4-nitrophenoxy)benzoic acid: SnCl22H2O = 1:3.35. ^ EFFECT: possibility of obtaining acid in minimal time with high output and high degree of purity. ^ 4 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104311408-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104311408-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2577545-C1 |
| priorityDate | 2009-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.