http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2408936-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40564a13f6a73b84e2b8e8c9e15d1e44 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G09B23-28 |
| filingDate | 2009-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d846ca6ca4fae4ec9ffd4d1e1b4add66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab9fa1907870c5cd889f107db3fb7205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_984e5c733b2f7170c3484dfb158e7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0099f2900e9457b0af92a344df8b61bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ae87d2131cf5e457113bd8468c5e859 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb60365f44766099bfe7e53c2ccfbded http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82a96779bfe05eb74a157acc03858d25 |
| publicationDate | 2011-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2408936-C1 |
| titleOfInvention | Method for modeling chloride-calcium arrhythmia in case of l-name-induced deficit of nitrogen oxide in experiment |
| abstract | FIELD: medicine. ^ SUBSTANCE: invention may be used to model chloride-calcium arrhythmia in case of L-NAME-induced deficit of nitrogen oxide. For this purpose daily once, blocker of endothelial NO-synthase, L-nitroarginine, methyl ether, is introduced intraperitoneally in dose of 25 mg/kg for 7 days. On completion of administering L-NAME, on the eighth day starting from experiment, animals are narcotized (chloral hydrate, 300 mg/kg), and stream infusion of 10% solution of calcium chloride is done into femoral vein in dose of 200 mg/kg with simultaneous registration of ECG with the help of electrocardiograph "Malysh EK1T-04" in the second standard lead. Extent of proarrhythmic action of L-NAME is assessed by percentage of survived animals, by the time of arrhythmia occurrence from start of stream infusion of 10% solution of calcium chloride into femoral vein, by nature of arrhythmia development and rate of heart contractions. ^ EFFECT: method provides for creation of model of chloride-calcium arrhythmia in case of L-NAME-induced deficit of nitrogen oxide, taking into account NO-dependent mechanisms of arrhythmia development. ^ 1 ex |
| priorityDate | 2009-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.