http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2408731-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c05590a83f885056ebb2b6909727ae93 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate | 2008-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97b234dc9f94c94767b0c29a3a2d57a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16b29413b64abcac7e7e5afc5f7b6220 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_034f2aad059c976573c757123b1ede0c |
| publicationDate | 2011-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2408731-C2 |
| titleOfInvention | Method to produce useful metabolite |
| abstract | FIELD: medicine. n SUBSTANCE: invention represents method to produce useful metabolite by fermentation of mix of primary source of carbon and secondary source of carbon, using bacterium of Enterobacteriaceae family, modified so that flows for recycling of primary source of carbon, such as carbohydrates or glycerin, and secondary source of carbon, such as ethanol, are separated in this bacterium. Method includes cultivation of bacterium in nutrient medium and extraction of metabolite from culture broth, besides, bacterium has increased expression of mutant alcohol dehydrogenase resistant to aerobic inactivation, reinforced with expression of mutant gene rthA, giving resistance to high concentrations of threonine, by deletion of gene coding threonine dehydrogenase, and is capable of production of useful metabolite selected from group consisting of glutamate, proline, threonine, lysin, aspartate, asparagine, methionine, serine, valine, leucine, isoleucine, cysteine, arginine and pyrimidines, by fermentation of mixture of primary source of carbon, such as carbohydrates or glycerin, and secondary source of carbon, such as ethanol, and is additionally modified so that flows of carbohydrates or glycerin and ethanol are divided through weakening of expression of gene (genes), coding their pyruvate kinase. n EFFECT: invention makes it possible to produce useful metabolites with high extent of efficiency. n 13 cl, 2 dwg, 1 tbl, 9 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2546237-C1 |
| priorityDate | 2008-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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