http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2408570-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76b6305c90835afa958bb677347f6fbe |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-563 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-313 |
| filingDate | 2009-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1800a4b0492c9075a8708177d57da674 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1d166911913db4e57fa9f593ac217f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d185c1d4aa41966a67419997f9c7015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2317352cc90c82676ba5032a2650545 |
| publicationDate | 2011-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2408570-C1 |
| titleOfInvention | Method of producing 2-(2-alkyl(dialkyl)amino)adamantylalkyl(aryl)ketones |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to chemical derivatives of adamantane and specifically to a novel method of producing 2-(2-alkyl(dialkyl)amino)adamantyl-alkyl(aryl)ketones of general formula R=-NHCH 3 : R 1 =Et,-CH 2 -CH=CH 2 ; : R 1 =Me, Et,-CH 2 -CH=CH 2 , Ph,-CH 2 Ph; : R 1 = Me, Etwhich can be used as intermediate products in synthesis of certain biologically active substances. The novel method involves reacting 2-alkylamino(dialkylamino)-2-cyanoadamantanes from the group: 2-methylamino-2-cyanoadamantane, 2-N-piperidino-2-cyanoadamantane, 2-N-morpholino-2-cyanoadamantane with Grignard reagents from the group: methylmagnesium iodide, ethylmagnesium bromide, allylmagnesium chloride, phenylmagnesiuim bromide, benzylmagnesium chloride in a medium of dry diethyl ether or a tetrahydrofuran-ether mixture in molar ratio of reagents equal to 1:2-2.03, respectively, at temperature 30-45°C for 4-5 hours. n EFFECT: wider range of adamantane derivatives, design of a method for synthesis of novel adamantane derivatives with high output. n 9 ex |
| priorityDate | 2009-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.