| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a method for synthesis of purine nucleoside 5'-aminoimidazole-4-carboxamide riboside (AICAR) and a Bacillus subtilis strain VKPM V-10167 - producer of AICAR. AICAR is obtained by culturing modified Bacillus subtilis bacteria in a suitable culturing medium. The modified bacteria used are Bacillus subtilis bacteria, obtained through successive introduction of mutations purR, purH::Em R , PurĪ L and P rpsF -prs. n EFFECT: disclosed invention widens the range of methods for microbiological synthesis of AICAR and enables to engineering of the strain which produces AICAR for realising this method. n 2 cl, 1 dwg, 2 tbl, 11 ex |