| abstract |
FIELD: medicine. n SUBSTANCE: invention refers to medicine, namely to oncology. The compound- conjugate antibody-medicinal agent is proposed with formula I: Ab-(L-D) p , where one or more molecules of maytanazoid medicinal agents (D) are covalently binded by L to the antibody huMAb4D5-8 (Trastuzumab) (Ab), which binds to the HER2 receptor and inhibits tumor cell growth, overexpressing HER2 receptor. n EFFECT: also a pharmaceutical composition is proposed which contains the specified compound, and a method of treating malignant tumor using this composition. n 20 cl, 8 tbl, 10 ex, 17 dwg |